PRELIMINARY DATA ON THE ROLE OF CONTRAST ENHANCED ULTRASOUND (CEUS) IN EARLY DIAGNOSIS AND STAGING OF RHEUMATOID ARTHRITIS

Authors

  • Trapanese Ersilio Interventional Ultrasound of Breast - ASL Salerno Italy.
  • Scognamiglio Umberto Interventional Ultrasound in infectious diseases departement - D.Cotugno Hospital Naples Italy.
  • Amato Patrizia MD, Rheumatologist - ASL Salerno Italy.
  • Tarro Giulio Emeritus Professor: President Foundation de Beaumont Bonelli for Cancer Research Naples Italy.

Keywords:

Rheumatoid arthritis, CEUS, biomarkers

Abstract

This paper is concerning with Rheumatoid Arthritis (RA) and the use of CEUS in the diagnosis and staging of the disease. 51 patiens were studed for this clinical syntoms, radiology and biomarkers. The contrast enhanced ultrasound allowes to estabilish an early diagnosis and staging of RA by monitoring the vascular progression of the synovial membrane. There are good prospectives for further confirmation of the methodology.

References

I. Altucci P. and Tarro G., 2014. Value of Etio-pathogenesis in Internal Madicine. Policlinico Sez. Med. 2014; 121: 61-81. Doi.10.7353/polmed.2014.121.061.

II. Arit F., Chalopin C, Muns A., Meixensberger J., Lindner D., 2016. Intraoperative 3D contrast-enhanced ultrasound (CEUS): a prospective study of 50 patients with brain tumours. Pub Med, April 2016

III. Berghin E. Johansson T., Sundin U., Jidell E., Wadell G., Hallmans G., Rantap-Dahlqvist S., 2006. Radiological outcome in rheumatoid arthritis is predicted by presence of antibodies against cyclic cirtrullinated peptide before and at disease onset and by IgA-RF at disease onset. Ann Rheum Dis. 2006;65:453–458.

IV. Chang S., Zhao L., Chen D., 2014. CEUS value judgment of rheumatoid arthritis knee synovitis. 2014;30:444–448.

V. Dai L. Zhu L.J., Zheng D.H., Mo Y.Q., Wei X.N., Su J.H., Pessler F., Zhang B.Y., 2010. Elevated serum glucose-6-phosphate isomerase correlates with histological disease activity and clinical improvement after initiation of therapy in patients with rheumatoid arthritis. J Rheumatol. 2010;37:2452–2461.

VI. Damjanov N. Radunovic G., Prodanovic S., Vukovic V., Milic V., Simic Pasalic K., Jablanovic D., Seric S., Milutinovic S., Gavrilov N., 2012. Construct validity and reliability of ultrasound disease activity score in assessing joint inflammation in RA: comparison with DAS-28. Rheumatology (Oxford) 2012;51:120–128.

VII. Dessein P.H., Joffe B.I., Stanwix A.E., 2004. High sensitivity C-reactive protein as a disease activity marker in rheumatoid arthritis. J Rheumatol. 2004;31:1095–1097.

VIII. De Zordo T., Mlekusch S.P., Feuchtner G.M., Mur E., Schirmer M., Klauser A.S., 2007. Value of contrast-enhanced ultrasound in rheumatoid arthritis. Eur J Radiol. 2007:222–230.

IX. Forslind K., Larsson E.M., Eberhardt K., Johansson A., Svensson B., 2004. Magnetic resonance imaging of the knee: a tool for prediction of joint damage in early rheumatoid arthritis. Scand J Rheumatol. 2004;33:154–161.

X. Frisell T., Hellgren K., Alfredsson L., Raychaudhuri S., Klareskog L., Askling J., 2016. Familial aggregation of arthritis-related diaseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden. Ann Rheum Dis. 2016 Jan; 75(1): 183-9. Doi:10.1136/annrheumdis-2014-2016133. Epub 2014 Dec 12.

XI. Gibofsky A., 2014. Epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis: A Sunopsis. AM J Manag Care. 2014 May: 20(7Suppl): S128-35.

XII. Hartung W., Kellner H., Strunk J., Sattler H., Schmidt W.A., Ehrenstein B., Fleck M., Backhaus M., 2012. Development and evaluation of a novel ultrasound score for large joints in rheumatoid arthritis: one year of experience in daily clinical practice. Arthritis Care Res (Hoboken) 2012;64:675–682.

XIII. Kyburz D., Gabay C., Michel B.A., Finckh A., 2006. Physicians of SCQM-RA Are bone erosions detected by magnetic resonance imaging and ultrasonography true Erosions? A comparison with computed tomography in rheumatoid arthritis metacarpophalangeal joints. Arthritis Res Ther. 2006;8:110.

XIV. Kyburz D., Gabay C., Michel B.A., Finckh A., 2011. The long-time impact of early treatment of rheumatoid arthritis on radiographic Progression: a population-based cohort study. Rheumatology (Oxford)2011;50:1106–1110.

XV. Li S.L., Lv G.R., Hu M.G., 2014. Significance of ultrasound evaluation score of rheumatoid arthritis. 2014;30:266–269.

XVI. Pincus T., 2008. Limitations of a quantitative swollen and tender joint count to assess and monitor patients with rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2008;66:216–223.

XVII. Rossini M., Rossi E., Bernardi D., Viapiana O., Gatti D., Idolazzi L., Caimmi C., Derosa M., Adami S., 2014. Prevalence and incidence of rheumatoid arthritis in Italy. Rheumatol Int. 2014 May: 34(5): 659-64. Doi:10.1007/s00296-014-2974-6. Epub 2014 Mar. 9.

XVIII. Szkudlarek M., Court-Payen M., Jacobsen S., Klarlund M., Thomsen H.S., Østergaard M., 2003. Inter observer agreement in ultrasography of the finger and toe joints in rheumatoid arthritis. Arthritis Rheum. 2003;48:955–962.

XIX. Tarro G. and Altucci P., 2014. Mycoplasmas and mycoplasmosis: 20 years ago. Il Policlinico Sez. Prat. 2014; 121: 229-245.

XX. Yazici Y., Sokka T., Pincus T., 2009. Radiographic measures to assess patients with rheumatoid arthritis:Advantages and limitations. Rheum Dis Clin North Am. 2009;35:723–729.

XXI. You L.L., Zheng Y.Y., Wang Z.G., 2014. Ultrasound score progression of rheumatoid arthritis. 2014;16:256–258.

XXII. Westwood M., Joore M., Grutters J., Redekop K., Armstrong N., Lee K. Gloy V., Raatz H., Misso K., Severens J., Kleijnen J., 2013. Contrast-enhanced ultrasound using Sono Vue® (Sulphur hexafluoride microbubbles) compared with contrast-enhanced computed tomography and contrast-enhanced magnetic resonance imaging for the characterization of focall liver lesions and detection of liver metastases: a systematic review and cost-effectiveness analysis. Pub Med.

Additional Files

Published

15-08-2016

How to Cite

Trapanese Ersilio, Scognamiglio Umberto, Amato Patrizia, & Tarro Giulio. (2016). PRELIMINARY DATA ON THE ROLE OF CONTRAST ENHANCED ULTRASOUND (CEUS) IN EARLY DIAGNOSIS AND STAGING OF RHEUMATOID ARTHRITIS. International Education and Research Journal (IERJ), 2(8). Retrieved from https://ierj.in/journal/index.php/ierj/article/view/381