CORRELATION BETWEEN ISCHEMIC HEART DISEASE AND CHEMOTHERAPY

Authors

  • Sukhyun Kim Research Scholars Program, Harvard Student Agencies, In collaboration with Learn with Leaders

Keywords:

Chemotherapy, Ischemic Strokes, Venous Thrombosis

Abstract

Ischemic stroke is a condition diagnosed when a blood clot or malignant particle reduces or stops the blood flow to a part of the body. Chemotherapy is a treatment used to cure cancer by killing fast-growing cells redundant to its malignancy. Numerous cancer treatments have shown a statistical relationship with ischemic diseases. Through previous studies and statistics, this research paper will focus on the positive correlation between ischemic heart disease and chemotherapy. This is mainly due to the cause of venous thrombosis (VTE), a side effect generated by drugs used in neoadjuvant chemotherapy and chemotherapy. Substances such as colony-stimulating factors (CSF) and erythropoiesis-stimulating agents (ESA) are examples of substances that generate venous thrombosis. Venous thrombosis is a condition in which a patient’s blood flow is impeded through blood clots in the blood vessel and leads to a thrombotic stroke, the most common form of an ischemic stroke. This subject shows significance in the field of medical science and medicine as it shows what factors of drugs used in chemotherapy influence the human blood vessels. Limitations exist in this paper as the lack of resources resulted in the paper being based on pure literature reviews from previous academic papers. Furthermore, specific sources that have been used in the paper were published a decade ago. This research aims to understand the extent of chemotherapy’s influence on ischemic strokes and the factors of chemotherapy that cause ischemic strokes. This research paper was written using evidence derived from the experiments and conclusions of previous academic papers. It emphasizes the danger and addresses certain risks of chemotherapy, aiming to be a catalyst for the development of drugs that may combat ischemic strokes in the future.

References

I. Abt NB; Bydon M; De la Garza-Ramos R; McGovern K; Olivi A; Huang J; Bydon A; (n.d.) Concurrent neoadjuvant chemotherapy is an independent risk factor for stroke, all-cause morbidity, and mortality in patients undergoing brain tumor resection. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia https://pubmed.ncbi.nlm.nih.gov/25065847/

II. Centers for Disease Control and Prevention (2023, July 24). Information for health care providers on infections during chemotherapy. Centers for Disease Control and Prevention. https://www.cdc.gov/cancer/preventinfections/providers.htm

III. Dardiotis, E., Aloizou, A.-M., Markoula, S., Siokas, V., Tsarouhas, K., Tzanakakis, G., Libra, M., Kyritsis, A. P., Brotis, A. G., Aschner, M., Gozes, I., Bogdanos, D. P., Spandidos, D. A., Mitsias, P. D., & Tsatsakis, A. (2019, March). Cancer-associated stroke: Pathophysiology, detection and management (review). International journal of oncology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365034/

IV. Du, X. L., Zhang, Y., & Hardy, D. (2016). Associations between hematopoietic growth factors and risks of venous thromboembolism, stroke, ischemic heart disease and myelodysplastic syndrome: findings from a large population-based cohort of women with breast cancer. Cancer causes & control : CCC, 27(5), 695–707. https://doi.org/10.1007/s10552-016-0742-5

V. Du, X. L., & Zhang, Y. (2015). Risks of Venous Thromboembolism, Stroke, Heart Disease, and Myelodysplastic Syndrome Associated With Hematopoietic Growth Factors in a Large Population-Based Cohort of Patients With Colorectal Cancer. Clinical colorectal cancer, 14(4), e21–e31. https://doi.org/10.1016/j.clcc.2015.05.007

VI. Esteva, F. J., & Hortobagyi, G. N. (2006). Comparative assessment of lipid effects of endocrine therapy for breast cancer: implications for cardiovascular disease prevention in postmenopausal women. Breast (Edinburgh, Scotland), 15(3), 301–312. https://doi.org/10.1016/j.breast.2005.08.033

VII. Haddad, T. C., & Greeno, E. W. (2006). Chemotherapy-induced thrombosis. Thrombosis research, 118(5), 555–568. https://doi.org/10.1016/j.thromres.2005.10.015

VIII. Grisold, W., Oberndorfer, S., & Struhal, W. (2009). Stroke and cancer: a review. Acta neurologica Scandinavica, 119(1), 1–16. https://doi.org/10.1111/j.1600-0404.2008.01059.x

IX. Jespersen, C. G., Nørgaard, M., & Borre, M. (2014). Androgen-deprivation therapy in treatment of prostate cancer and risk of myocardial infarction and stroke: a nationwide Danish population-based cohort study. European urology, 65(4), 704–709. https://doi.org/10.1016/j.eururo.2013.02.002

X. Kuan AS;Teng CJ;Wu HH;Su VY;Chen YT;Chien SH;Yeh CM;Hu LY;Chen TJ;Tzeng CH;Liu CJ; (n.d.). Risk of ischemic stroke in patients with ovarian cancer: A nationwide population-based study. BMC medicine. https://pubmed.ncbi.nlm.nih.gov/24661584/

XI. Li SH, Chen WH, Tang Y, Rau KM, Chen YY, Huang TL, Liu JS, Huang CH. (n.d.). Incidence of ischemic stroke post-chemotherapy: A retrospective review of 10,963 patients. Clinical neurology and neurosurgery. https://pubmed.ncbi.nlm.nih.gov/16412836/

XII. Navi, B. B., & Iadecola, C. (2018, May). Ischemic stroke in cancer patients: A review of an underappreciated pathology. Annals of Neurology. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021225/#R32

XIII. Rogers L. R. (2003) Cerebrovascular complications in cancer patients. Neurologic clinics, 21(1), 167–192. https://doi.org/10.1016/s0733-8619(02)00066-x

XIV. Saini, V., Guada, L., & Yavagal, D. R. (2021). Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions. Neurology, 97 (20 Suppl 2), S6–S16. https://doi.org/10.1212/WNL.0000000000012781

XV. Saynak, M., Cosar-Alas, R., Yurut-Caloglu, V., Caloglu, M., Kocak, Z., & Uzal, C. (2008). Chemotherapy and cerebrovascular disease. Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 13(1), 31–36.

XVI. Types of strokes. The Texas Heart Institute. (2020, September 30). https://www.texasheart.org/heart-health/heart-information-center/topics/types-of-strokes/

XVII. U.S. Department of Health and Human Services. (n.d.). What is venous thromboembolism?. National Heart Lung and Blood Institute. https://www.nhlbi.nih.gov/health/venous-thromboembolism

Additional Files

Published

15-12-2023

How to Cite

Sukhyun Kim. (2023). CORRELATION BETWEEN ISCHEMIC HEART DISEASE AND CHEMOTHERAPY. International Education and Research Journal (IERJ), 9(12). Retrieved from https://ierj.in/journal/index.php/ierj/article/view/3203