EVALUATION OF THE ACTION OF STATINS IN THERAPEUTIC MANAGEMENT OF DIABETIC DYSLIPIDEMIA, CASES OF TYPE 2 DIABETES IN LUBUMBASHI.

Authors

  • Arsène Tshikongo Kabamba Faculté des Sciences pharmaceutiques, Université de Lubumbashi, RD Congo
  • Glauber Kalubandika Mbayo Faculté des Sciences pharmaceutiques, Université de Lubumbashi, RD Congo
  • Yves Bwalya Kisunka Faculté des Sciences pharmaceutiques, Université de Lubumbashi, RD Congo
  • Danny Mbikayi Mukeba Faculté des Sciences pharmaceutiques, Université de Lubumbashi, RD Congo
  • Richie Kyandabike Kipenge Faculté de Médecine, Université de Lubumbashi, RD Congo
  • Dominique Kalonda Mudimbi Faculté des Sciences pharmaceutiques, Université de Lubumbashi, RD Congo
  • Zet Kalala Lukumwena Faculté de Médecine Vétérinaire, Université de Lubumbashi, RD Congo
  • Albert Otshudi Longanga Faculté des Sciences pharmaceutiques, Université de Lubumbashi, RD Congo. Université Libre de Bruxelles (ULB), Belgique

Keywords:

Statins, Type 2 diabetes, Lubumbashi

Abstract

Context

Type 2 diabetes is preceded by a long asymptomatic phase that is often overlooked, but in which the body undergoes many changes. Diabetics have a significantly increased risk of cardiovascular diseases such as angina, heart attack, stroke or peripheral vascular disease. These complications of diabetes affecting large arteries are the particular consequences of dyslipidemia.

Goal

The objective of this study was to evaluate the effectiveness of statin group of drugs used in the drug management of dyslipidemia of type 2 diabetes in the city of Lubumbashi in the Democratic Republic of Congo.

Methods

This is a cross-sectional study conducted from June to December 2014 in Lubumbashi (DR Congo).

40 patients with type 2 confused sex with 20 drugs in the statin family, fibrates under 10 and 10 in the statin-fibrate combination were in this descriptive study. Alongside the classical laboratory tests, analysis of lipid parameters were carried out: HDL cholesterol, LDL cholesterol, total cholesterol and triglyceride.

Results

Different levels of serum lipids were analyzed recorded based on lipid-lowering therapy. Type 2 diabetes, obese of the first class, who were treated with combination statin + fibrate, presented at least one month after treatment a normal lipid levels in all respects.

Conclusion

Statins are potent molecules able to stabilize lipids. However these drugs are sometimes ineffective in the treatment of dyslipidemia in type 2 diabetes when used as monotherapy. Hence the need to add to them other molecules to enhance their lipid-lowering effect through a synergy of action.

References

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Additional Files

Published

15-10-2015

How to Cite

Arsène Tshikongo Kabamba, Glauber Kalubandika Mbayo, Yves Bwalya Kisunka, Danny Mbikayi Mukeba, Richie Kyandabike Kipenge, Dominique Kalonda Mudimbi, Zet Kalala Lukumwena, & Albert Otshudi Longanga. (2015). EVALUATION OF THE ACTION OF STATINS IN THERAPEUTIC MANAGEMENT OF DIABETIC DYSLIPIDEMIA, CASES OF TYPE 2 DIABETES IN LUBUMBASHI. International Education and Research Journal (IERJ), 1(3). Retrieved from https://ierj.in/journal/index.php/ierj/article/view/19

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