CALCIUM CALMODULIN-DEPENDENT PROTEIN KINASE II (CAMKII) VERSATILE PLAYER FOR SYNAPTIC PLASTICITY

Authors

  • Atiq Hassan Department of Neuroscience, Avalon University School of Medicine, 122-124 Sta. Rosaweg Curacao, Netherland Antilles.
  • M. V. Raghavendra Rao Department of Neuroscience, Avalon University School of Medicine, 122-124 Sta. Rosaweg Curacao, Netherland Antilles.
  • Yogesh Acharya Department of Neuroscience, Avalon University School of Medicine, 122-124 Sta. Rosaweg Curacao, Netherland Antilles.
  • Sateesh Arja Department of Neuroscience, Avalon University School of Medicine, 122-124 Sta. Rosaweg Curacao, Netherland Antilles.
  • Reshma Fateh Department of Neuroscience, Avalon University School of Medicine, 122-124 Sta. Rosaweg Curacao, Netherland Antilles.

Keywords:

Calcium/calmodulin-dependent protein kinase II, long-term Potentiation, long-term Depression, short-term potentiation, synaptic plasticity

Abstract

Calcium ions (Ca2+) play significant role in signal transduction pathways. Ca2+ signaling is mediated through several Ca2+-binding proteins, including calmodulin (CaM). CaM is a regulatory protein that modulate the activity of several signaling molecules those are crucial for synaptic plasticity including Ca2+/calmodulin-dependent protein kinase or (CaM kinase II). CaMKII is a multifunctional signaling protein that comprises 1%–2% of the protein in brain. Due to its extraordinary abundance within neuronal cells, CaMKII has been believed to act as both a structural protein as well as an enzyme during synaptic plasticity. CaMKII is a key synaptic signaling protein, and involved in numerous forms of synaptic plasticity such as LTP. CaMKII has been one of the most extensively studied signaling protein that play a pivotal role in various forms of synaptic plasticity and memory in hippocampal and other neurons.  The studies have shown CaMKII is involved in numerous forms of synaptic plasticity including long-term potentiation (LTP), long-term depression (LTD) and short-term potentiation (STP). These all form of plasticity forms the basis for learning,  memory and cognition.

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15-07-2017

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Atiq Hassan, M. V. Raghavendra Rao, Yogesh Acharya, Sateesh Arja, & Reshma Fateh. (2017). CALCIUM CALMODULIN-DEPENDENT PROTEIN KINASE II (CAMKII) VERSATILE PLAYER FOR SYNAPTIC PLASTICITY. International Education and Research Journal (IERJ), 3(7). Retrieved from https://ierj.in/journal/index.php/ierj/article/view/1261

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Vol. 3 No. 7 (2017): JULY ISSUE, INTERNATIONAL EDUCATION AND RESEARCH JOURNAL

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