• Ali Javadpour MD. Associate professor in geriatric psychiatry
  • Mina Dehghani MD. Resident in psychiatry
  • Arash Mani Ph.D. Assistant professor in Cognitive Neuroscience
  • Mohamad Reza Shenavar MD.Resident in psychiatry


Background: Bipolar disorder in the elderly could fall into two types: Early onset and  late onset type(onset after 50 years old).Earlier studies  reported different clinical characteristics and correlates for  subtypes  of  late life  bipolar disorder , so that late onset bipolar disorder have more medical co morbidity, less over activity and higher  resistance to treatment. This study was designed to explore those postulated differences in clinical and socio demographics among old age individuals with early onset versus those with late onset bipolar disorder.

Method: In a cross sectional study 60 elderly with bipolar disorder and a healthy normal control group with mean age of 63/5 years old were recruited. Bipolar disorder was diagnosed using DSMIV-TR. Additionally; Young mania rating scale was used to detect clinical symptoms of resent manic episode. To explore potential correlated factors communication illness rating scale (CIRS), Cognitive failure questionnaire and paykle life event scale were administered to study group.

Results: Data analyses showed an increased sexual interest, more sleep disturbance and higher family history for bipolar disorder in patients with early onset type of bipolar disorder. (p=0/05). On the other hand, there were more vascular risk factors especially cerebral strokes  among  late onset type of bipolar disorder.

Discussion: Differences in clinical presentation and correlated factors between early versus late onset type of bipolar disorder  lead to the idea of a distinctiveness of late onset type of the disorder. Further studies investigating neurobiological biomarkers and structural neuroimaging are recommended.


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How to Cite

Ali Javadpour, Mina Dehghani, Arash Mani, & Mohamad Reza Shenavar. (2015). CLINICAL CHARACTERISTICS AND CORRELATES OF LATE LIFE BIPOLAR DISORDER . International Education and Research Journal (IERJ), 1(2). Retrieved from