IS GENETIC OBESITY A BOON OR BANE?
Keywords:
Body mass index (BMI), Syndromic obesity, Monogenic Forms of ObesityAbstract
Obesity is a heritable trait influenced by genetics, epigenetic, and the environment Obesity is a universal epidemic and is devoted to global morbidity and mortality interfered via the improvement of fatty liver disease, type 2 diabetes (T2D), cardiovascular (CVD), and other diseases. It is an aftereffect of an uplifted caloric absorption, an inactive lifestyle, and a genetic, as well as an epigenetic susceptibility Obesity, is a condition that affects human health adversely. Obesity is a common disease caused by multiple factors. It has been reported heredity plays a strong role in obesity development. Because of this complex, multifactorial pattern, diseases and traits such as obesity are called complex genetic traits. There are sequences of variants present in the population that increases or decreases an individual’s risk for obesity in their environment. Gene involves in the development of common forms of obesity, thereby identifying pathways that are causal in patients, will guide clinicians and scientists in designing more effective therapies and in identifying high-risk individuals for early intervention. This is inconsistent with the absence of strong signatures of selection at single nucleotide polymorphisms (SNP’S) linked to obesity. Most SNPs are identified by comparing two chromosomes that are common and shared throughout the world: 90% of such SNPs will be seen again at a frequency of at least 1%. Most of these common variants probably have no functional consequence and are essentially the equivalent of genetic dialect or random differences in spelling with no real significance.
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