CAUSE, EPIDEMIOLOGY, MODE OF TRANSMISSION AND MANAGEMENT OF COVID-19

Madhu Bala, Anil Bajaj

Abstract


Corona virus is a pandemic disease according to WHO (World health organisation). COVID-19 is caused by acute respiratory syndrome coronaviruse2 (SARAS-CoV-2). Initially, COVID-19   was started in Wuhan, a central china in  December, 2019.  The CFR  (case fatility rate) depend upon the availibity of health care, age and health problem  with in the population.On 12 January 2020, the World Health Organization temporarily named the new virus as 2019 novel corona virus (2019‐nCoV). The sporadic outbreaks of new types of CoVs remind us that CoVs  are severe  threat to affect the  global public  health. According to WHO, 87,137 cases was confirmed across worldwide since the beginning of the epidemic. Out of these, 2977 (3.42%) have been fatal. About 92% (79,968) of the confirmed cases were recorded in China, where almost all the deaths were also recorded (2,873, 96.5%) It is highly likely that new CoVID outbreaks are unavoidable in the future due to changes of the climate, ecology and increased interactions of human with animals. Thus, there is an urgent need to develop effective therapies and vaccines against COVID-19. At present, there is no vaccine or antiviral treatment for human corona virus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak.  There are general methods, which include broad-spectrum antiviral drugs and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual corona viruses, are used to discover the pontential antiviral treatment of human pathogen corona virus. Antiviral drugs includes Lopinavir, Ritonavir, Nucleoside analogues, Neuraminidase inhibitors, Remdesivir, RNA synthesis inhibitors (such as TDF, 3TC), anti-inflammatory drug, could be the drug treatment options for 2019-nCoV. Therefore, the efficacy and safety of these drugs for 2019- nCoV still need to be further confirmed by clinical experiments.

Keywords


COVID-19, CFR, 3 TC, TDF, SARAS-CoV-2.

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