• Shruti Madderla RBVRR Women’s College of Pharmacy, Osmania University, Barkatpura, Hyderabad, India
  • Dr. P. Tripura Sundari RBVRR Women’s College of Pharmacy, Osmania University, Barkatpura, Hyderabad, India


curcumin, chitosan, ionic gelation method


Curcumin was naturally occurring agent with poor solubility also with a bioavailability of 3%. It is useful in many potential pharmacological effects including anti-inflammatory, antibacterial, antioxidant and anticancer activities. It was also proved against cardiovascular disease, Alzheimer’s disease, liver problems, rheumatic arthritis, diabetics, Parkinson’s disease and neurological disorders. To enhance its solubility, permeability and bioavailability nanoparticle technology is very much useful.

      In the present work attempts were made to prepare the curcumin loaded nanoparticles by using chitosan as polymer, tripolyphosphate as cross linker using ionic gelation method. The seven prepared formulations were evaluated for various parameters like entrapment efficiency, In Vitro drug release, particle size, Zeta potential and SEM analysis. Among all the Preparations F6 formulation was best in terms of  Drug content of 70.9%, Entrapment efficiency of 71.3%, Drug release of 89.9%, Particle size of 122.8 nm with Zeta potential of -22.3mV and was also in accordance with particle size in nano range by SEM analysis  in ionic gelation method. The present study conclusively demonstrated that the solubility of drug was improved.


Anand P, Thomas SG, Ajaikumar B, Kunnumakkara AB, Sundaram C, Harikumar KB et al. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem Pharm. 2008; 7(6):1590- 1611.

Das R, Kasoju N, and Bora U. Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells. J. Nanomedicine: Nanotechnology, Biology, and Medicine 2010; 6: 153–160.

Mirza Ali Mofazzal Jahromi 1, Sharafaldin Al-Musawi 2, Majid Pirestani 3, Mahdi FasihiRamandi 1, Kazem Ahmadi 4, Hajar Rajayi 5, Zuhair Mohammad Hassan 5, Mahdi Kamali 6,Reza Mirnejad 1,* Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe, natural and effective antibiotic inhibits the infection of Staphylococcus

aureus and Pseudomonas aeruginosa in vivo November 2014;Iranian Journal of Biotechnology •

Recovita S, Vasiliu S, Popa M and Luca C. Polysaccharides Based on Micro and Nanoparticles Obtained by Ionic Gelation and Their Applications as Drug Delivery Systems. Revue Roumanie de Chimie 2009; 54 (9) :709-718.

Tiyaboonchai W. Chitosan nanoparticles: a promising system for drug delivery. Naresuan University Journal 2003; 11(3): 51-66.

P Senthil Kumar and N Punniamurthy: Formulation development and characterization of curcumin loaded solid lipid nanoparticles for improved aqueous solubility and bioavailability; The Pharma Innovation Journal 2017; 6(4): 07-11

PRAGNA shelata, VINOD K. Mandowaraa*, DEEPAK G. Guptaa, SHETULV. Patela ; Formulation of curcuminoid loaded solid lipid nanoparticles in order to improve oral bioavailability; international journal of pharmacy and pharmaceutical sciences ;2015 ;vol 7, issue 6

Daniela Chirio , Marina Gallarate, Elena Peira , Luigi Battaglia , Loredana Serpe and Michele Trotta; Formulation of curcumin-loaded solid lipid nanoparticles produced by fatty acids coacervation technique; Journal of Microencapsulation, 2011; 28(6): 537–548

Hongyu Ji1, Jingling Tang2, Mengting Li1,2, Jinmei Ren1,2, Nannan Zheng1,2, and Linhua Wu1,2 ; Curcumin-loaded solid lipid nanoparticles with Brij78 and TPGS improved in vivo oral bioavailability and in situ intestinal absorption of curcumin; Informa Healthcare 2014;23(2): 459–470

Sarabjot kaur, Ujjwal Nautyal*, Ramandeep Singh, Satvinder Singh, Anita Devi; Nanostructure Lipid Carrier (NLC): the new generation of lipid nanoparticles; Asian Pac. J. Health Sci., 2015; 2(2): 76-93

Additional Files



How to Cite

Shruti Madderla, & Dr. P. Tripura Sundari. (2018). FORMULATION & EVALUATION OF CURCUMIN LOADED CHITOSAN TRIPOLYPHOSPHATE NANOPARTICLES. International Education and Research Journal (IERJ), 4(12). Retrieved from