FORMULATION & EVALUATION OF CURCUMIN LOADED CHITOSAN TRIPOLYPHOSPHATE NANOPARTICLES

Abstract

Curcumin was naturally occurring agent with poor solubility also with a bioavailability of 3%. It is useful in many potential pharmacological effects including anti-inflammatory, antibacterial, antioxidant and anticancer activities. It was also proved against cardiovascular disease, Alzheimer’s disease, liver problems, rheumatic arthritis, diabetics, Parkinson’s disease and neurological disorders. To enhance its solubility, permeability and bioavailability nanoparticle technology is very much useful.

      In the present work attempts were made to prepare the curcumin loaded nanoparticles by using chitosan as polymer, tripolyphosphate as cross linker using ionic gelation method. The seven prepared formulations were evaluated for various parameters like entrapment efficiency, In Vitro drug release, particle size, Zeta potential and SEM analysis. Among all the Preparations F6 formulation was best in terms of  Drug content of 70.9%, Entrapment efficiency of 71.3%, Drug release of 89.9%, Particle size of 122.8 nm with Zeta potential of -22.3mV and was also in accordance with particle size in nano range by SEM analysis  in ionic gelation method. The present study conclusively demonstrated that the solubility of drug was improved.