SERUM VITAMIN D LEVEL AMONG TYPE 2 DIABETES MELLITUS SUBJECTS IN MULLANA, HARYANA
Keywords:Type 2 Diabetes Mellitus, Vitamin D, Insulin Resistance, β-¬cell dysfunction
Diabetes mellitus is a metabolic malady characterized by the presence of hyperglycemia due to defective insulin secretion, defective insulin action or both. India has over 60 million diabetics out of a population of 1.3 billion. Vitamin D refers to a group of fat-soluble secosteroids. Vitamin D deficiency is a significant public health problem. Numerous studies across various regions in India indicate that approximately 70-90% of apparently healthy population is vitamin D deficient. Studies have shown low vitamin D association with an increased risk of non-musculoskeletal diseases, such as type 2 diabetes mellitus since vitamin D deficiency is related to insulin secretion, β-cell dysfunction and insulin resistance.
Materials and Methods: The study was conducted in the Department of Biochemistry in collaboration of Department of Medicine, MM Institute of Medical Sciences and Research, Haryana. 100 T2DM diagnosed patients were taken. The concentration of serum 25OH vitamin D, was estimated by Chemiluminescence Imunoassay (CLIA) in two steps.
Results: Out of 100 T2DM patients 53 were males and 47 were females. The average serum vitamin D level among T2DM cases was 19.09±5.34 ng/ml. 10% of cases were highly vitamin D deficient and the remaining cases had insufficient vitamin D. Among insufficient vitamin D cases, about 29% had vitamin D level 10-19 ng/ml and about 71% had 20-29 vitamin D level. No cases had sufficient as well as possible toxicity amount of vitamin D level. It was found all T2DM patients were vitamin D deficient and insufficient independent of their gender and age group.
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