SERUM VITAMIN D LEVEL AMONG TYPE 2 DIABETES MELLITUS SUBJECTS IN MULLANA, HARYANA

Authors

  • Vijay Chaudhary PhD Scholar, Department of Biochemistry, MM Institute of Medical Sciences and Research, MM University, Mullana, Ambala, India, 133203.
  • Dr. Shalini Gupta Professor, Department of Biochemistry, MM Institute of Medical Sciences and Research, MM University, Mullana, Ambala, India, 133203.
  • Dr. PD Gupta Professor and Head, Department of Medicine, MM Institute of Medical Sciences and Research, MM University, Mullana, Ambala, India, 133203.
  • Dr. Suvarna Prasad Professor and Head, Department of Biochemistry, MM Institute of Medical Sciences and Research, MM University, Mullana, Ambala, India, 133203.

Keywords:

Type 2 Diabetes Mellitus, Vitamin D, Insulin Resistance, β-¬cell dysfunction

Abstract

Diabetes mellitus is a metabolic malady characterized by the presence of hyperglycemia due to defective insulin secretion, defective insulin action or both. India has over 60 million diabetics out of a population of 1.3 billion. Vitamin D refers to a group of fat-soluble secosteroids. Vitamin D deficiency is a significant public health problem. Numerous studies across various regions in India indicate that approximately 70-90% of apparently healthy population is vitamin D deficient. Studies have shown low vitamin D association with an increased risk of non-musculoskeletal diseases, such as type 2 diabetes mellitus since vitamin D deficiency is related to insulin secretion, β-­cell dysfunction and insulin resistance.

Materials and Methods: The study was conducted in the Department of Biochemistry in collaboration of Department of Medicine, MM Institute of Medical Sciences and Research, Haryana. 100 T2DM diagnosed patients were taken. The concentration of serum 25OH vitamin D, was estimated by Chemiluminescence Imunoassay (CLIA) in two steps.

Results: Out of 100 T2DM patients 53 were males and 47 were females. The average serum vitamin D level among T2DM cases was 19.09±5.34 ng/ml. 10% of cases were highly vitamin D deficient and the remaining cases had insufficient vitamin D. Among insufficient vitamin D cases, about 29% had vitamin D level 10-19 ng/ml and about 71% had 20-29 vitamin D level. No cases had sufficient as well as possible toxicity amount of vitamin D level. It was found all T2DM patients were vitamin D deficient and insufficient independent of their gender and age group.

References

I. Arokiasamy P, Parasuraman S, Sekher TV, Lhungdim H. (2013). India: Study on global Ageing and adult health (SAGE), Wave 1. International Institute for Population Sciences. Geneva: World Health Organization.

II. World Health Organization, Geneva. (2016). Global report on diabetes.

III. Hyderabad: National institute of nutrition. (2012). Diet and nutritional status of rural population, prevalence of hypertension and diabetes among adults and infant and young child feeding practices-report of third survey.

IV. Ghoneim AH, Al-Azzawi MA, Elmasry SA, Nasr MY and AboZaid MMN. (2015). Association of vitamin D status in the pathogenesis of chronic obstructive pulmonary disease. EJCDT, 64, p.805-812.

V. Gupta A and Gupta R. (2014). Vitamin D deficiency in India: prevalence, causalities and interventions. Nutrients, 6, p.729-775.

VI. Nimitphong H and Holick MF. (2013). Vitamin D status and sun exposure in Southeast Asia. Dermatoendocrinol, 5, p.34-37.

VII. Lhamo Y, Chugh PK and Tripathi CD. (2016). Vitamin D supplements in the Indian market. Indian J Pharm Sci, 78, p.41-47.

VIII. Szabó A. (2011). Skeletal and extra-skeletal consequences of vitamin D deficiency. Orv Hetil, 152, p.1312-1319.

IX. Boucher BJ. (2011). Vitamin D insufficiency and diabetes risks. Curr Drug Targets, 12, p.61-87.

X. Stout RW. (1994). Glucose tolerance and ageing. J R Soc Med, 87, p.608-609.

XI. Nuttall FQ. (2015). Body mass index: obesity, BMI, and health: a critical review. Nutr Today, 50, p.117-128.

XII. Wilmot E and Idris I. (2014). Early onset type 2 diabetes: risk factors, clinical impact and management. Ther Adv Chronic Dis, 5, p.234-244.

XIII. Anjana RM and Mohan V. (2016). Diabetes and physical activity. Indian J Med Res, 143, p.530-531.

XIV. Mitri J and Pittas AG. (2014). Vitamin D and diabetes. Endocrinol Metab Clin North Am, 43, p.205-232.

XV. National Diabetes Data Group. (1979). Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes, 28, p.1039.

XVI. American Diabetes Association. (2017). Classification and diagnosis of diabetes. Diabetes Care, 40, p. S11-S24.

XVII. Bayani MA, Akbari R, Banasaz B and Saeedi F. (2014). Status of Vitamin-D in diabetic patients. Caspian J Intern Med, 5, p.40-42.

XVIII. Taheri E, Saedisomeolia A, Djalali M, Qorbani M and Civi MM. (2012). The relationship between serum 25-hydroxy vitamin D concentration and obesity in type 2 diabetic patients and healthy subjects. J Diabetes Metab Disord, 11, p.16.

XIX. Mukherjee B and Patra S. (2014). Prevalence of vitamin D deficiency in type-2 diabetes mellitus patients and its correlation with glycemic control. Int J Bioassays, 3, p.3313-3317.

XX. Chaudhary S, Thukral A, Tiwari S, Pratyush DD and Singh SK. (2013). Vitamin D status of patients with type 2 diabetes and sputum positive pulmonary tuberculosis. Indian J Endocrinol Metab, 17, p.S670-S673.

XXI. Laway BA, Kotwal SK and Shah ZA. (2014). Pattern of 25 hydroxy vitamin D status in North Indian people with newly detected type 2 diabetes: a prospective case control study. Indian J Endocrinol Metab, 18, p.726-730.

XXII. Siddiqui MH, Saxena R, Verma S and Sharma GD. (2016). 25-hydroxy vitamin D level in type 2 diabetics and non-diabetics: a comparative study. Int J Pharmaceut Clin Res, 8, p.284-288.

XXIII. SV AK, Nanda SK, N B, K R, Dinakaran A and Ray L. (2016). Evaluation of vitamin D status and its correlation with glycated haemoglobin in type 2 diabetes mellitus. Biomed Res, 0970, p.1683.

XXIV. Bajaj AH, Gadre S, Sukumaran S and Vidhate D. (2015). Correlation of Vitamin D defciency with type 2 diabetes and metabolic traits in the Indian population. Int J Basic Clin Pharmacol, 4, p.1224-1227.

XXV. Sheth JJ, Shah A, Sheth FJ, Trivedi S, Lele M and Shah N et al. (2015). Does vitamin D play a significant role in type 2 diabetes? BMC Endocr Disord, 15, p.5.

XXVI. Tsiaras WG and Weinstock MA. Factors influencing vitamin D status. (2011). Acta Derm Venereol, 91, p.115-214.

XXVII. Kadi HA. (2014). Vitamin D status in Saudi women with type 2 diabetes mellitus: a case-control study. Int J Recent Advan Multidisc Res, 01, p.33-36.

XXVIII. Daga RA, Laway BA, Shah ZA, Mir SA, Kotwal SK and Zarga AH. (2012). High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India. Arq Bras Endocrinol Metab, 56, p.423-428.

Additional Files

Published

15-06-2017

How to Cite

Vijay Chaudhary, Dr. Shalini Gupta, Dr. PD Gupta, & Dr. Suvarna Prasad. (2017). SERUM VITAMIN D LEVEL AMONG TYPE 2 DIABETES MELLITUS SUBJECTS IN MULLANA, HARYANA. International Education and Research Journal (IERJ), 3(6). Retrieved from http://ierj.in/journal/index.php/ierj/article/view/1181