• Dr. Kanupriya Gupta Senior Research Fellow, Faculty of Dental Sciences, IMS, BHU, Varanasi (U.P.)


Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein causes systemic amyloidosis, a serious inflammatory disorder. Amyloidosis may manifest as periodontal destruction that leads to severe chronic periodontitis. Proper periodontal treatment may alleviate systemic inflammatory mediators caused by the amyloidosis.


Lachmann HJ, Goodman HJB, Gilbertson JA, Gallimore JR, Sabin CA, Gillmore JD, et al.: Natural history and outcome in systemic AA

amyloidosis. N Engl J Med 2007, 356:2361-2371.

Urieli-Shoval S, Linke RP, Matzner Y: Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states. Curr Opin Hematol 2000, 7:64-69.

Laiho K, Tiitinen S, Kaarela K, Helin H, Isomaki H: Secondary amyloidosis has decreased in patients with inflammatory joint disease in Finland.Clin Rheumatol 1999, 18:122-123.

Singh G, Kumari N, Aggarwal A, Krishnani N, Misra R: Prevalence of subclinical amyloidosis in ankylosing spondylitis. J Rheumatol 2007, 34:371-373.

Yalçınkaya F, Çakar N, Acar B, Tutar A, Güris ¸ H, Elhan AH, et al.: The value of the levels of acute phase reactants for the prediction of familial Mediterranean fever associated amyloidosis: a case control study.Rheumatol Int 2007, 27(6):512-522.

De Beer FC, Mallya RK, Fagan EA, Lanham JG, Hugles GR, Pepys MB: Serum amyloid-A protein concentration in inflammatory diseases and its relationship to the incidence of reactive systemic AA-amyloidosis. Lancet 1982, 2:231-234.

Benson MB, Cohen AS: Serum amyloid. A protein in amyloidosis, rheumatic and neoplastic diseases. Arthritis Rheum 1979, 22:36-42.

Ebersole JL, Machen RL, Steffen MJ, Willmann DE: Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp Immunol 1997, 107:347-352.

Taylor BA, Tofler GH, Carey HMR, Morel-Kupp MC, Philcox S, Carter TR, et al.:Full-mouth tooth extraction lowers systemic inflammatory and thrombotic markers of cardiovascular risk. J Dent Res 2006, 85(1):74-78.

Slade GD, Offenbucher S, Beck JD, Heiss G, Pankow JS: Acute-phase inflammatory response to periodontal disease in US population. J Dent Res 2000, 79:45-57.

D'Aiuto F, Nibali L, Parkar M, Suvan J, Tonetti MS: Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J Dent Res 2005, 84:269-273.

Rocken C, Shakespeare A: Pathology, diagnosis and pathogenesis of AA amyloidosis. Virchows Arch 2002, 440(2):111-122.

Sohar E, Gafni J, Pras M, Heller H: Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med 1967, 43:227-253.

Cengiz K: Uncommon aetiology in renal amyloidosis. Acta Clinica Belgica 2005, 60:109-113.

Nasr SH, Schwarz R, D'Agoti VD, Markowitz GS: Paraplegia, proteinuria, and renal failure. Kidney Int 2006, 69:412-415.

Waldenström H: On the formation and disappearance of amyloid in man. Acta Chir Scand 1928, 63:479-530.

Gertz MA, Lacy MQ, Dispenzieri A: Amyloidosis, recognition,confirmation, prognosis, and therapy. Mayo Clin Proc 1999, 74:490-494.

Hazenberg BPC, Grond J, van den Top D, Bijzet J, Limburg PC, Van Rijswijk MH: Immunohistochemical detection of amyloid AA in formaline-fixed paraffin-embeded rectal biopsies with the monoclonal anti-human SAA antibody. Edited by: Natving JB, Forre O, Husby G, et al. Dordrecht the Netherlands: Kluwer Academic; 1991:809-812. Rev. 86.2 in Amyloid and amyloidosis 1990

Van Der Waal I, Fehmers MC, Kraal ER: Amyloidosis: its significance in oral surgery. Review of the literature and report of a case. Oral Surg Oral Med Oral Pathol 1973, 36:469-481.

Cengiz Mİ, Bağcı H, Bal S, Yiğit S, Cengiz K: Periodontal disease in familial Mediterranean fever patients: from inflammation to amyloidosis. JPeriodontal Res 2009, 44:354-361.

Puchtler H, Sweat F, Levine M: On the binding of Congo red by amyloid.J Histochem Cytochem 1962, 10:355-364.

Glurich I, Grossi S, Albini B, Ho A, Shah R, Zeid M, et al.: Systemic inflammation in cardiovascular and periodontal disease: comparative study. Clin Diagn Lab Immunol 2002, 9:425-432.

Khoury S, Dusek JJ, Anderson GB, Wigneswaran N: Systemic amyloidosis manifesting as localized, severe periodontitis. J Am Dent Assoc 2004,135:617-623.

Stoopler ET, Sollectio TP, Chen SY: Amyloid deposition in the oral cavity:a retrospective study and review of the literature. Oral Surg Oral MedOral Pathol 2003, 95(6):674-680.

Bergström J: Periodontitis and smoking: an evidence-based appraisal.Journal of Evidence Based Dental Practice 2006, 6:33-41.

Omori H, Tsuji M, Sata K, et al.: Correlation of C-reactive protein with disease severity in CT diagnosed emphysema 2009. Respirology 2009, 14(4):551-558.

Robins SL: Disease of immunity. In Pathologic basis of disease Volume 99.6th edition. Edited by: Cortan RS, Kumar V, Collins T. Saunders Co,Philadelphia PA; 1999:188-259.

Nibali L, Ready DR, Parker M, Brett PM, Wilson M, Tonetti MS, et al.: Gene polymorphism and the prevalence of key periodontal pathogens. JDent Res 2007, 86:416-420.

Additional Files



How to Cite

Dr. Kanupriya Gupta. (2017). AMYLOIDOSIS OF ORAL CAVITY . International Education and Research Journal (IERJ), 3(5). Retrieved from